Manuscript collection 3- Maren papers

Thomas H. Maren Papers

Physical Description:   33.9 linear feet  (76 boxes)

Arrangement Notes:  Collection is mostly arranged according to research interests, experiments and notes, many of the research files also contain correspondence with pharmaceutical companies.  There are, additionally, separate correspondence and patent correspondence files.

Biography: Dr. Thomas H. Maren was born 1918, and passed away August 16, 1999. He was the first chair of the Department of Pharmacology and Therapeutics at the University of Florida College of Medicine.  He came to UF in 1955, shortly before the first medical school class matriculated.  He remained chair until 1978, and he continued to work as a graduate research professor until his death on August 15, 1999.  Dr. Maren was a devoted scientist and teacher who was known for his love of both science and the humanities.

Dr. Maren attended Princeton University and earned a degree in chemistry in 1938.  He took a job at Wallace Laboratory, but soon returned to Princeton to earn a Ph.D. in English literature.  However, during World War II, Dr. Maren was recruited to study anti-parasitic agents at the Johns Hopkins School of Hygiene and Public Health.  There, he met E.K. Marshall, chair of Pharmacology, who convinced him to explore pharmacology and selected him for a pilot program that sent basic scientists to medical school.  He graduated from the Johns Hopkins School of Medicine in 1950.  Dr. Maren then returned to industry at the chemotherapy division of the American Cyanamid Company, where he began studying carbonic anhydrase and its inhibitors.  His early work contributed to the first effective oral diuretic, Diamox (acetazolamide), a carbonic anhydrase inhibitor, which also happened to lower intraocular pressure.

After coming to UF, Dr. Maren continued his work on carbonic anhydrase.     Dr. Maren also conducted research in comparative physiology at the Mount Desert Island Biological Laboratory on the Maine Coast.  He studied carbonic anhydrase and other methods of acid secretion and bicarbonate resorption in many marine animals every summer in Maine for 40 years.  Comparative physiology gave him particular insight into the roles of carbonic anhydrase in humans, especially the secretion of cerebrospinal fluid.  In the mid-1970s, Dr. Maren returned to his early work on glaucoma medication, convinced that carbonic anhydrase inhibitors could be applied topically to the eye.  He thus laid the groundwork for the development of topical glaucoma medications including Trusopt® (dorzolamide), and Cosopt ®  (dorzolamide hydrochloride-timolol maleate).  He is perhaps best known for this groundbreaking research on topical glaucoma medications, which preserve the sight of millions.

While at UFCOM, Dr. Maren was committed to education.  He developed the medical pharmacology curriculum for second year students and a clinical therapeutics course for senior students.  His lectures were studded with literary allusions, such as the influence of opiates on Samuel Coleridge in writing Kubla Kahn.  Princeton University granted Dr. Maren a Master’s degree in English Literature fifty years after the fact so that he might teach a survey course for medical students on English literature.  Dr. Maren wished to give medical students the opportunity to develop a love of literature.  The Maren Reading Room enables students to learn about great literature and the history of the profession of medicine. 

Agency Note:  Some materials pertain to Dr. Maren’s earlier tenure at Merck as well as his medical school days.  Most covers his time at the UF-COM from 1955-1999.

Contents note:  Collection contains school notebooks and lecture notes, as well as extensive correspondence files, notes on research projects and manuscripts, diaries and notes on trips, slides and tapes from a trip to China, history files and non-science manuscripts, information and correspondence on patents. 

Box 1

Reprints

Box 2

• Pharmacology 1, Research 1947
• Thyroid, Post Pituitary, April 1948
• Pharmacology Book 4, Posterior Pituitary, Ascorbic Acid p. 130
• Antihistamine, Art. Fever, November 1, 1949
• Book 6, Dogs-Rabbit Renal, Mice obese
• Write-ups for experimental Labs 

Box 3

• Gross Anatomy Notebook
• Physiology Lab and Lectures, 1946-1947
• Surgery, Radiology, Obstetrics, 3^rd Year 

Box 4

• Hopkins Notes
• Pathology Notebook
• Bacteriology and Parasitology Notebook 

Box 5

• Pharmacology and DFD, 1969
• DFD Walter Reed, 1969
• DFD, Malaria, 1969
• Malaria, DFD
• Malaria, Hopk Class
• Chemotherapy of Filiariosis
• Annual Progress Report, Contract No. DA-49-193-MD-2947, Department of the Army
• Manual for the Microscopical Diagnosis of Malaria in Man
• Lecture – Trypanosomes
• Filariasis (Recent) Parasites
• Chemotherapy of Filariasis 

Box 6

Notebooks- temporarily on display in Thomas H. Maren Medical Student Reading Room 

Box 7

• Allergan, 1981-1986
• Pharmatec – Cyclodextran Agreement
• Eye Grant (Through 3-1-86)
• NIH Grant CA B1297
• History of CAI
• Tables, 1960-Present
• Graphs – CA – Present
• Glaucoma Reprints
• Merck Files – Confidential
• Alcon, 1990-1991, Correspondence
• Alcon File
• Alcon, 1992-1995, Patent 90-96
• Grant – Competing Renewal – 1991-1995 

Box 8

• E.K. Marshall, Memoir Correspondence
• E.K. Marshall, Obit. Material
• E.K. Marshall, Family

Box 9

• TM – Biography
• Maren Biography
• Phi Kappa Phi
• Maren Biography
• Hopkins, Precursor Study
• Instructions for New Employees
• Lilly Fiasco
• Employment – Lilly 

Box 10

• Notes on Hopkins Admissions Policies
• Program for the Abel Centennial Meeting of the American Society for Pharmacology and Experimental Therapeutics
• Centenary of the Birth of John Jacob Abel
• Collected Reprints of John J. Abel, Volume One, 1888-1908
• Flexner, Pharmacology, and the Future
• Excerpt from the Yale Journal of Biology and Medicine
• The Impact of Neurology of 40 Years advances in Pharmacology
• History and Highlights of Finnish Pharmacology
• The Riddle of Man’s Ancestry
• Mayer, Edmund, 1943, Book Review, On Growth and Form
• Review:  Biochemistry and Morphogenesis (Joseph Needham)
• American Medicine in the Twentieth Century:  Some Personal Insights
• History of Medicine:  The Treatment of Syphilis
• Hiawathas Lipid
• Triazure and Public Drug Policies, By Seymour Shubin
• Publications of V. Everett Kinsey, Ph.D.
• The Birth of Scientific Pharmacology, By Ilo Kabin
• Alfred Newton Richards, 1876-1966, A Biographical Memoir By Carl Schmidt
• Urine Formation
• A Study of the Acquired Resistance of Fixed Tissue Cells Morphologically Altered through Processes of Repair
• T.J. Maclagan and the Treatment of Rheumatic with Salicin
• The Introduction of Chloral Hydrate into Medical Practice, By Thomas C. Butler
• Francis John Worsley Roughton, 1899-1972, By Q.H. Gibson, F.R.S.
• August Wilhelm Hofmann (1818-1892), A.S. Travis
• Bulletin of the History of Medicine
• Fritz Lipmann:  In memoriam
• Medical School Education:  A Student’s Perspective, By Ludwig W. Eichna, M.D.
• Accidents in the Pursuit of Knowledge, By Otto Krayer
• Development of Concepts in Rochester, New York, in the 1940’s; by Arthur B. Otis and Hermann Rahn
• Physiological, Chemical and Clinical Studies on Pituitary Principles, By Dr. John J. Abel
• Elements of Pharmacology, by Dr. Oswald Schmiedeberg
• Hopkins Medical News, Volume 8, no. 6, Fall 1984
• August and Marie Krogh and Respiratory Physiology
• John Jacob Abel at Michigan:  The Introduction of Pharmacology in to the Medical Curriculum
• John Jacob Abel, A Portrait by Paul D. Lamson
• The New England Journal of Medicine, Feb 18, 1983, page 404
• Reflections:  Mathematics and Creativity
• The 1981 Sollmann Oration, by Avram Goldstein,  “The Three-Dimensional Sturcture of Pharmacology”
• The Evolution of Experimental Pharmacology as a biological science:  The Pioneering Work of Buchheim and Schmiedeberg
• With Apologies to J. Masefield:  Base Fever

 Box 11

• Presidential Address:  William Stewart Halsted – A Profile of Courage, Dedication, and Scientific Search for Truth.  By Daniel B. Nunn, MD
• Origins of American Pharmacology
• Reflections on Reductionism, By Steven Rose
• Dionysians and Apollonians
• Reflections on the Pioneers of Neurohumoral Transmission, By George B. Koelle
• Sodium-independent Active Transport of Potassium in the Isolated Midgut of the Cecropia Silkworm
• Evidence for ‘Electrogenic’ Active Sodium Transport in an Epithelial Membrane, Feb 16, 1963
• Kampo Medicine from the Viewpoint of Western Medicine, By E. Leong Way, Ph.D
• Hemoglobin and the Origins of th eConcept of Allosterism, By John T. Edsall
• The Nobel Prize in Physiology or Medicine
• The Medical Profession and Congenital Malformations (1900-1979)
• Some Biophysical Experiments from Fifty Years Ago
• Early Danish Contributions to Oxygen and Acid-base Research
• Schmiedeberg in Strassburg 1872-1918:  The Making of Modern Pharmacology
• The Development of the Physical Chemistry of Proteins, 1898-1940, by John T. Edsall
• Some Early History of Cold-Insoluble Globulin, by John T. Edsall
• Physical Chemistry at Harvard Medical School:  The First Twenty Years, by John T. Edsall
• Anne Bradstreet, the First American Poetess, and her Father, Governor Thomas Dudley
• Scientific Basis for the Support of Biomedical Science, Julius H. Comroe, Jr., and Robert D. Dripps
• The Introduction of Chloral Hydrate into Medical Practice, by Thomas C. Butler
• Chemical Structure and Pharmacological Action:  A chapter in the History of 19^th Century Molecular Pharmacology.  By William F. Bynum
• Obstetric Anesthesia  and Concepts of Placental Transport:  A Historical Review of the Nineteenth Century, By Donald Caton, M.D.
• Letter to Dr. Maren
• Annals of Anesthetic History, Obstetric Anesthesia:  The First Ten Years, By Donald Caton, M.D.
• The Apology of a Second Class Man, by Horace W. Davenport
• Historical Records of Scientific Activity:  The Survey of Sources for the History of Biochemistry and Molecular Biology, By John T. Edsall and David Bearman
• Aspects of the History of Biochemistry, by John T. Edsall
• The Outsider, by John Archibald Wheeler
• Life of a Biochemist
• Tribute to Dr. V. Everett Kinsey
• David Keilin, 1887-1963
• Valdemar Henriques, 19 April 1864- 4 December 1936
• Jones, Charles Colcock
• David A. Karnofsky Memorial Lecture:  Thoughts on Chemical Therapy
• Verities In Medical Education Prefatory Address, by Ludwig W. Eichna, M.D.
• Scientific Evidence versus Therapeutic Demand:  The Introduction of the Suflfonamides Revisited, By Barron H. Lerner, M.D.
• Some Aphorisms on Research and Writing
• Experiments concerning the Question of Secretion of Phenolsulphonephthalein by the Renal Tubule, By A.N. Richards and John B. Barnwell.
• Biographical Memoir of John Jacob Abel, 1857-1938; By WM. DeB. MacNider
• Warren Harmon Lewis, 1870-1964;  A Biographical Memoir by George W. Corner
• The Presentation of a Portrait of Dr. Phillip Bard, June 17, 1971
• The Story of Penicillin:  The View from Oxford in the Early 1950’s, by Wlofgang K. Joklik
• Micropuncture Study of the Mammalian Urinary Concentrating Mechanism:  Evidence for the Countercurrent Hypothesis.
• Roughton Biography
• Historical Note:  Methemoglobinemia—Long Ago and Far Away, by Quentin Gibson
• Some Notes on the Roughton Family of Kettering by Professor F.J.W. Roughton
• George Scatchard, 1892-1973.  A biographical memoir by John T. Edass and Walter H. Stockmayer
• Theodore Shedlovsky, 1898-1976, A Biographical Memoir by Raymond M. Fuoss
• Notes on the Foundations of Basic Science at the John Hopkins School of Medicine
• The life and death of laboratory teaching of medical physiology:  A personal narrative
• J.H. Burn:  An appreciation
• Carbonic Anhydrase and its inhibitors (including Sulfonamides); Benzothiadiazices and Furosemide
• The Business of Discovery in the Medical Sciences, by Charles B. Huggins, M.D.
• Brass Plaque Commemorating Francis Roughton
• History of Physiology Department at University of Florida, By Arthur B. Otis
• Drug Development and Industrial Pharmacy:  Forty Years of Molecular Modification
• Introduction to Special Number, American Journal of Insanity, containing Addresses at Opening of the Henry Phipps Psychiatric Clinic;  The purpose of the Psychiatric Clinic;  Closing Remarks
• Masters of Medicine by J. Arthur Meyer;  Department of Pharmacology
• The Chemotherapy of Tuberculosis:  Including the Use of Streptomycin
• From the Mountains to the Labs:  A brief Summary of the People and their Studies on which Rests most of what we Know Today
• Paracelsus:  Founder of Medical Chemistry
• Pathological Science:  Langmuir, December 18, 1953
• Yellow Fever Epidemic in Gainesville
• Ephedrine and Related Substances, by K.K. Chen and Carl F. Schmidt
• Centenary of the Birth of John Jacob Abel (4 copies)
• Philip Bard 1898-1977
• Otto Krayer 1899-1982  A biographical memoir by Avram Goldstein (3 copies)
• Gerty Theresa Cori 1896-1957  A biographical memoir by Joseph Larner
• Some Personal History and Reflections from the Life of a Biochemist  By John T. Edsall
• Francis John Worsley Roughton 1899-1972  By Q.H> Gibson, F.R.S.
• Stephen Polyak, M.D.  1889-1955
• Some Historical Reflections on Drug Metabolism  by Thomas C. Butler, M.D.
• To What Extent are the Physiological Effects of Carbon Dioxide due to Hydrogen Ions?
• Theories of General Anesthesia, by Thomas C. Butler
• Partition Coefficients, by Lewils L. Engel and Priscilla Carter
• Homer William Smith 1895-1962
• The Ontogenesis of One Physiologist
• Program for the Dedication of the Homer W. Smith Laboratory at the Mount Desert Island Biological Laboratory
• Biographical Memoir of John Jacob Abel by WM. DeB. MacNider
• John Jacob Abel, A Portrait, by Paul D. Lamson
• Post Card from Horace Davenport
• The Life and Death of Laboratory Teaching of Medical Physiology by Horace W. Davenport
• Masters in Gastroenterology, Volume 4 No. 2 
• Department of Pharmacology and Therapeutics Student Seminar
• How to succeed in Research without Being a Genius 

Box 12

• Junior Honors, 1976-1980
• Junior Honors, 1981-1982
• Junior Honors, 1983-1985
• Junior Honors, 1896-1987-1988
• Junior Honors, 1989
• Junior Honors, 1991-1995
• 1990, Junior Honors, Pharmacology
• 1992, Junior Honors, Pharmacology
• 1996, Junior Honors, Pharmacology
• 1997, Junior Honors
• Junior Honors, 1998
• 1998 Junior Honors
• Junior Honors, 1999 

Box 13

• Literature Course
• American Literature, 1993
• Literature Course, English and American
• Literature Course 192 

Box 14

• Report on Preclinical Medical Education, 1956
• Medical Education – Report on Trip to Europe to study Medical Education
• Curriculum Com. – Letters of General Info
• Minutes/Ideas – Letters on Curriculum:  ROC
• Robert Wood Johnson Foundation (Curriculum)

 Box 15

• MDIBL, 1953-1966
• Maren Symposium, MDIBL, June 1997
• Centennial, 1998, MDIBL
• MDIBL History
• MDIBL History
• Mt Desert Notes 

Box 16

• Class Records, Early 1960’s
• Class of 1960-1961, Pharm. Class Distribution 

Box 17

• Green, Pharmacology, Sinai, 1996
• Pharmacology and Pharmaceuticals
• Chemotherapy History
• Pharmacology Dept. History
• History:  Pharmacol Industry
• Pharmacology 

Box 18

• Human Subjects
• University of Florida History
• UF History
• Florida – 20 Years
• COM – Dept. Biochem
• COM Project one

Box 19

• Symposium – TM, Bar Harbor, 1989
• Vancouver Symposium, Drane Book, 1953
• London Drug Symposium, 1973
• Benzon Symposium III, 1970Benzon Symposium IV, 1971
• Australia Symposia, 1980-1983 

Box 20

• Nat Flux, 1962
• Dog Liver, 1945
• MS 222, 1968
• Bohn Effect, Summer 1976
• Alkalosis, 1959
• CA – Gastric Secretions, 1959
• Obese Mice, 1951
• Noble Gases, 1936
• Cushing’s Disease, 1953
• Wallace Lab- Unfubushed Mss
• HK Atpase
• Early CS research
• Early Bohn Stuff
• 1964-1965, Sears Olson Plots
• MS 222 

Box 21

• Eye, Schoenwald Group
• Cornea
• International Eye Meeting, 1984, (Spain – Berlin)
• Eye Penetration
• Timolol – Vogit, 1988, Flow and Nat
• Aqueous Flow
• Adelhauser Cornea
• Edelhauser Cornea, 1983-1988
• Aqueous Humor Penetration Calc. – General
• Eye Grant, Competing Renewal, 1986-1991

 Box 22

• CA Renal
• Valfin Chapters and Renal Acidification
• CO₂  Equilibria in Kidney, Kidney Int. 7/27/78
• Renal NH₄⁺ loss, Atkinson and Burke
• COE – Nephrology and Urinalysis
• Old Alkolosis-misc. Nechay expts.
• Aminophylline – Naqua Paper:  New Orleans Talk
• Drug Effects on Renal Excretion – Schering, Feb. 1971
• Chlorothiazide – Schering 6040
• Dose Acetazolamide – Renal
• Nephritis:  Co-report:  Diamox #11
• Renal Pathology
• Anti-Diuretic
• CO₂^– Diffusion
• Defects in RTA due to Def. of  C.A.?
• RTA Study – Renal Tubular Acidosis
• Renal Handling of CA – Silbernagl, Sarasota 1986
• Smith Symposium 

Box 23

• Shark Kinetic Curves – 1978
• Inhibition Data In Vitro (37^o)
• CA Inhibitors – Eye
• Computing Flow Dependency in eye
• Carbonic Anhydrase inhibition
• Synthetic Carbonic Anhydrase
• A. Burgen Lecture 1992; Kinetics Drug Enzyme
• Tables – Chem – NaHCO₃
• Carbonic Anhydrase:  It’s Properties, Distribution and Significance for Carbon Dioxide Transport, by H. Van Goor
• Physiological Basis for the Action of Newer Diuretic Agents, by Karl H. Beyer and John E. Baer
• Chapter 3:  Carbon Dioxide
• Carbonic Anhydrase Inhibition and Physiological Function, by Horace W. Davenport
• The Blood-Brain Barrier, by Hugh Davson
• Chapter 43:  Carbonic Anhydrase, by F.J.W. Roughton and A.M. Clark
• The Use of Carbonic Anhydrase Inhibitors in Ophthalmology and Clinical Medicine
• Evolution and Regulation of the Carbonic Anhydrase Isozymes
• Genetics of the Mammalian Carbonic Anhydrases, By Richard E. Tashian
• Velocity of CO₂ Exchange in Muscle and Liver, by Gerolf Gros and S. Dodgson
• Molecular Genetics of Carbonic Anhydrase Isozymes
• Biochemical Review, Carbonic Anhydrase:  Update and New Horizons
• Mechanisms of active H⁺ secretion in the proximal tubule, by Peter Aronson
• Effects of Diuretics on Renal Transport of Potassium, by Gehard Giebisch
• Tubular Transport of Amino Acids and Small Peptides, by Stefan Silbernagl
• Renal Acidification Mechanisms, by Alpern, Warnock, and Rector
• Rapid Communication:  Invertebrate Red Blood Cell Carbonic Anhydrase
• Multiple Functions of Carbonic Anhydrase in the Crustacean Gill, by Raymond Henry
• The Effects of Drugs on Enzyme Systems, by F. Edmund Hunter, Jr., and Oliver Lowry
• Topical Carbonic Anhydrase Inhibitors, by Eve J. Higginbotham, MD
• Review:  Carbonic Anhydrases, by Harold F. Deutsch
• Chapter 33:  Carbonic Anhydrase, by Robert P. Davis
• Chapter 23:  Distribution and Functions of Carbonic Anhydrase in the Gastrointestinal Tract, by Erik R. Swenson
• Review Article:  Recent Research into the Nature of Cerebrospinal Fluid Formation and Absorption, by J. Gordon
• McComb, M.D.
• Multiple Roles of Carbonic Anhydrase in Cellular Transport and Metabolism, by Raymond Henry
• Role of Anions and Carbonic Anhydrase in Epithelia, by D.S. Parsons
• Transport of Oxygen and Carbon Dioxide, by F.J.W. Roughton 

Box 24

• Innsbruck Data – CA 1973
• Eveloff, Swenson, and Maren, 1977-1978, CA
• CA, Work Rate Constants
• Substrates for CA
• Maren Symposium, MDIBL, CA
• Plant Evolution of Carbonic Anhydrase
• Carbonic Anhydrase – DDT insecticides
• Carbonic Anhydrase, Diuretic Effects
• L662-5 Series 667-1186-87, Merck Correspondence regarding Testing
• 58-65 MDIBL Notes and Abstracts
• Brom, Acetazolam,   DE
• DFD
• Summary of Antipyretics work
• Cinchonic Acid – Inflammation
• Drug Pharmacology
• Tables – Comp. Acidosis

 Box 25

• Early Ocular CA – Literature
• Mouse CA Kimberly Hess
• Polymer Chemistry/Polymer bound CA 1993-1995
• 6/21/75 Physiol Events involving Carbonic Anhydrase
• CA inhib X Lack of Renal Resp., 1957
• CA Inhibition VII, 1957, Aug of Renal
• CA Inhib, 1X Comp of Renal Resistance, 1958
• CA Inhibition VIII, Aug. of Renal, 1958
• Vulgar Errors in the Use of CA Inhibitors
• Urodele MDIBL, 1981, MS
• Hagfish CA Primitive Enzyme 

Box 26

• Competitive Inhibition – Enzyme and Drug
• Carbonic Anhydrase Seminars, 1985-1987, Sarasota, Hoechst, Nephrology, Louisville, Richmond, Residents Rounds in Biology of Disease
• Misc. Ellison Testing Notes, Kidney Tubule Volume
• Pancreatic and Gastric Carbonic Anhydrase Inhibitors:  DIAMOX
• “Weird Sisters” Osteopetrosis Syndrome and Carbonic Anhydrase Deficiency
• Misc. Kinetic Notes – Liebman and Weir
• W-2388
• Musc. Studies:  Maine 1959-1960
• Paper and Notes:  Stockholm
• Drafts and Charts for in Vivo inhibition study
• Notes for RBC Paper
• Red Blood Cell Saturation by Diamox and Sulfonamides, Maren, Rab, Palmer
• Work with E.J. Ballintine:  Carbonic Anhydrase:  eye
• BALT 57 Paper – Loweing CSF pressure in Hydrocephalis
• DIAMOX:  Gen. Notes on 6063 Research
• Notes:  Red Blood Cell Paper
• Diamox:  Teratology Studies

Box 27

• Reduction of AG. Humor Sec. By Top. CA Inhibitor
• CA – Chemistry, Phys, Inhib, 1967
• Rate Constant Theory, Lit, Steiglitz, Laid Ler letters, Taylor
• Upsala, Holland 1982 Topical CA Inhibitors
• Forster Symposium 1976, Effect of C.A. Inhibition on ion equilibrium in S. Acanthias
• S. Acanthias Paper II, Work Charts Osmolarity
• CO₂ Effects of Carbonic Anhydrase – Abstracts 1957-1958
• Lidia Jankowska Manuscript, Effect of CA Inhibition on muscle CO₂ transport during contractions
• Muscle CA Inhibition and Kinetics, Fall 1980
• Hypokalemic Periodic Paralysis Data
• Hyperkalemia Periodic Paralysis, Hoskins – Notes
• Hypokalemic Periodic Paralysis Notes
• Charlottesville, 1984, Carbonic Anhydrase and CA Inhibitors
• Angle, Nov. 1958, Topical CA Inhibitors
• Misc. Inhibitors in Man and Rat

 Box 28

• Talks, 1968-1970, CA Model System, Kidney
• CA Lectures, 1972-1978
• Talks, 1985-1989
• Sarasota 1976, NY 1976- Talks
• Europe, 1977- General Activity
• Reick Lecture, Oct. 12, 1979;  Penn State, Feb 13, 1980
• Wurzburg – General CA Talk, 1982, Siubgrnagl Calc. 

Box 29

• Morphine (1)
• Morphine (2)
• Morphine (3)

 Box 30

• Talks, 1978-1979
• Hannover, 1981
• Gill 1985, Talks on Comp. H⁺
• Banff, 1986
• London, December 1989
• Louisville, 1989
• S-N Symposium – Muscle Titra, 1986-1989 Maine 1989 Neph.
• Talks, Chicago, Uppsolo, 1990
• Arvo 90 pH paper, Brechve and Maren
• Fanous Exp, 1992
• Papers Delivered, 1992
• 1998-Arnost Talk

 Box 31

• Theoretical and Exotic
• CA Inhibition VIII, IX, X, AM Cyanamid, 1958
• CA Inhibition VIII, AM Cyanamid, 1957
• Swenson and Maren, Paper – Roughton Equation
• TU and CA, Maine, Miami, Cambri DGG
• MDIBL Research, 192-92, CA inhib
• CA Inhib, Egg shell
• MDIBL – CSF Volume, Squalus, Blue dye
• Onter 1972, Squalus, FUU IDS
• Big Eye, Squalus, 73-74, Data cclc
• 22 Na⁺ Accession
• CA in the Kidney 

Box 32

• Clinical Study, Becker, 1976
• Red Cell – Maren and Couto Paper, 1979
• Rectal Gland
• Inhibition of AS and Certain in Vitro analysis
• Drug Effects on Cerebral Spinal Fluid Production
• Nicotine and Temperature
• Old Notebook Pages
• Analytical Experimentation
• L- 649, 522; L- 649, 473  (F for OH)
• Triflourmethazolamide (TFM)
• Data and Graphs and Calc.  0^o-37^o, Kinetics; Not Inhib.
• Enzyme Test
• Summer 1961, Raw Data
• Acetazolamide and Calc., Ethoxolamide and Chlorzolamide
• Summer 1960, Raw Data
• Temperature Expts. – Pyromen
• Carbamates
• Maine 57-60, Aq. – Cerebral Spinal Fluid, Raw Summaries
• W-2354 – 1969-70, Inflammatory 

Box 33

• MIDBL Abs,  68, Broder – CSF Fish Cat.
• CSF Notes 77-78, J. App Phys.
• Cheng Sayes Goodman Swingard-Hypothalamus of Rats, 1950
• Roma, London, Spolere, Louisville, CRS Talks
• Hypercapnia Fish, 71-72, CSF
• Old Lit.- Pituitary and Hypothalamus 

Box 34

• Wallace – Patent 60-69
• CA Inhib Patent:  Chem. Various CPDS
• Merck Patents
• Non-Merck Patents
• US Patents (THM)
• Patent and Thedphyline and HC Schering
• Merrell-License-Patent
• Wallace Patent Negotiations
• Heart-Lung Grant
• Alkang Patents 

Box 35

• Diflusional Study
• 1946 Solusti Bosan (SP?)
• 48, Mapharsge
• Angsthetics:  General and Local
• Triflouromethyl Compounds
• Antipyretics and Analgesia Lecture
• Cinchonic Acids – Literature
• Renal Drugs – Steroids
• Drug Distribution and Excretion
• Drug Activity-Physical Principles
• Drug Activity Paper, Maren/Wiley
• Chemotherapy – Antibiotics
• TBC and 13084, 1949-1953
• Antipyretic Activity of Cinchoninic Acid
• Sulfone Papers
• Chemotherapy – Parasites, TBC and Cancer

Box 36

• Merck, Feb 1987
• Merck Test A-F, 3/85
• Merck November 85, General; 405, 073
• Merck Data on L-652, 690 and L- 653, 760
• Merck and Trusopt Reprints-Basic Sci. (Folder #1)
• Merck and Trusopt Reprints – Clinical
• Merck and Trusopt Reprints – Basic Sci. (Folder #11)
• Merck L 658-259
• Merck 1987 Summary Letters to Friedman
• 1987-Merck Correspondence, Mar.-Dec.
• Merck Corresp – US/France, 1981-1986
• Merck Paper on Some Graham
• Merck Sharp and Dohme, 1957-1997 

Box 37

• 650, -719 Benzothoiophenes Merck
• Misc Compounds – Merck
• 927-Drug Distribution-Eye, 93-94
• L 654, 230
• Merck, 1981, General
• Merck Compound Lists:  Data, 1981-1986 

Box 38

• Cyanamid-CA essays and chemistry
• American Cyanamio/Storz Division
• Benzolamide Bibl-General Info, 1967-1974
• Biostatistics
• Cyanamid History
• Cyanamid-Correspondence, 1993
• Trip Reports-Cyanamid
• IOP Cyanamid
• Cyanamid Compounds
• Grant-American Cyanamid/Storz Div. 

Box 39

• Maren-China Trip Tapes (# 1&2)  1)  Tokyo-Hong Kong  2)  Hong Kong-PRC 3)Canton 6/1-6/2, Peicing 6/3-6/5  4)  Peking 6/5-6/7
• Maren China Trip Tapes (#3-4), 5)  Peking 6/8-6/11 6)Peking –Tien Su-Shanghai 6/11-6/14.  7)  Shanghai 6/14-6/16.  8)  Shanghai6/16, Nanking 6/17-18, Shanghai 6/19-20
• Maren China Trip Tapes (#5&6)  9) Shanghai, 6/20, 10) Canton6/24, HK  End also letter to L.L. and Instructions
• Maren China Trip Tapes (#7)  Final 
• China Slides 
• A personal Diary of a Trip to the People’s Republic of China in June, 1974, by T.H. Maren 

Box 40

• China, Reprints and Ref.
• China Trip, 1974 Talk
• China Trip, 1974 Committee-Herbal Pharmacology Delegation
• China Trip, 1974 Report-Burns
• China Trip, 1974 Report-Farusworth
• China Trip 1974 Report-Kupchan
• China Trip 1974 Working Report Supplement on Pharm Test and Procedures-Maren
• China Trip-1974 Report Meinwald
• China Trip-1974 Report Modell
• China Trip-1974 Report-Pettit
• China Trip 1974 Report-Schwartz
• China Trip 1974 Report-Tsuchitani
• China Trip 1974 Report-Wakeman
• China Trip 1974 Report-Way 

Box 41

• China Trip-1974-Misc. Info
• China Trip-1974-Diary Draft
• China Trip-Correspondence-1973-1976 

Box 42

• CSF Flow Data-Vogh
• Vogh CSf Notes-1974
• CSF Notes
• Plasma and CSF
• Metabolism-permeability CSF
• Effect of Hypercapnia on CSF HCO₃^–
• Wiggins-CSF

 Box 43

• Filiariasis, Baltimore trip 1951
• Filiariasis

 Box 44

• Diuretics/Renal Excretion Teaching
• Lakeside Diuretic Reiview
• Diuretic  Chapter 

Box 45

• Robins, 1987-89
• A.H. Robins Res-87-88
• Hoechst, 1986
• Wallace Labs
• Robins Co, 1988-1989
• Carbonic Anhydrase-Ledgrle, 1980
• Smith Klein and French Benza, Ethox, Diamox
• Schering
• Trusopt Corresp.
• Lederle Research, 1974-77
• Lederle Labs, Ind. Per. Paralysis, 1966-1986

Box 46

• Red Blood Cell Paper
• Red Cell/Trusopt/Dorz
• Aqueous PCO₂
• Daily Rat Measurements, 1949
• Dog Balance Data:  EKG
• Frankfurt 1984, Al ions and CSF, Al⁺⁺⁺
• 74-78, pH-NaHCO₃:PCO₂ 
• Ion Pairs Literature
• Ion Pairs Literature
• Anion Notes, 1978
• Giles, Filley, Butler, pH Gradients, Blood, Gas
• Acid Base
• Maren-Friedland-Rittmaster, Final MS 

Box 47

• Southern Salt, Water and Kidney Club
• Southern Salt, Water and Kidney Club-History
• Cinchonic Acid
• Misc. Diuretic
• Berliner Ch. 66 in the Kidney

 Box 48

• Hydrocephalus-(Jelks), 1959-1962, Robinson
• Hydrocephalic Talks-Duplicate Patient Material
• Diamox-Cerebral Dynamics Study
• Diamox:  Effect of C.A. Inhib. In K Exchange in Human RBS’s-Hoskins, Jarrell, Maren
• Diamox:  Hg, CO, Rep.10
• Diamox:  Carbonic Anhydrase:  Central Nervous System
• Diamox Data:  (Stamford) Unpublished Man
• Unpublished Data on Diamox:  Rabbits
• Unpublished Data on Diamox:  Rats
• N⁵ Diamox Derivatives
• Unpublished Talks:  DAMOX THM
• Chemical and Analytical Data (DIAMOX)
• Clin. And Exp. Epilepsy DIAMOX only
• Early Reports-DIAMOX, 1952-1956
• DIAMOX:  Early work Reprints
• Unpublished Data on Diamox:  Dogs

 Box 49

• Unpublished Electrolyte Diamox
• Lederle-Diamox
• Schwartz-Diamox exp.
• Diamox Homologues
• Pharmacokinetics Diamox
• C.S.F. Data-Jelks and Wiggins

 Box 50

• Ethoxzolamide Data Exp. Eye Res. Paper
• Beth Hoskins Corr. Hyperkalemic Disease-Acetazolamide
• Ethoxzolamide in vivo (Bar-Ilan)
• Chemical Structure Slides
• Sulfonamide Pharmacology
• 13494:  Sulfonamide
• 3/5/61:  Sulfonamide
• Sulfonamides Antibacterial Reprints, 1983 Lecture
• Sulfonamides
• Chemotherapy-Sulfonamides type SO₂N⁺

 Box 51

• Ethoxzolamide Paper, 1980
• Sulfonamides-Kinetics, 1983
• Sulfonamide Research 1980-85 (Volume I of II)
• Sulfonamide Res. 1980-1985 (Volume II of II)
• Sulfonamide 

Box 52

• Benzolamide 11,366 From 1963-66
• Benzolamide and related topics-Strassbarg Data
• Subacute Toxicity Study with a Benzolamide-Theophylline Combination in Dogs
• Benz. And Salicylate
• Summer 1995 Maine Benzolamide
• FDA Benzolamides
• Sterling-Winthrop Research Benzolamide
• 11,366 Pathological
• Wallace, 11,366 from 1967 testing (Benzolamide)
• Benzolamide, 1962
• Methyl Benzolamide
• FDA and Canadian-FDD material benzolamide Clinical Summaries-Wallace 

Box 53

• Methazolamide-Gainesville
• Methazolamide Analogies C series 1985
• Old Pharm-Meth, Acet.
• Methazolamide Pharm.  ’81-’88? 

Box 54

• FLA. History of Glaucoma
• Acidosis-Human and Eye
• Topical CA inhibitors for Glaucoma-Timoptic

 Box 55

• Hopkins Distinguished Alumnus award
• John Hopkins Scholar 1971
• Alcon Research Award 1989
• Oppelt Award
• Faculty Award for Research
• Weicker Award Correspondence
• Lasker Award

 Box 56

• Willard Thorp-History of Princeton
• John Hopkins Medical School
• “Cat” Talk
• Norse Explorations
• Opium-Coleridge, deQ, Johnson
• Wilson, Edmund

 Box 57

• Acetazolamide and Hyperkalemia 1974
• Acetazolamide
• Glucose Metabolism and Acetazolamide induced Teragenesis (Ellison)
• Acetazolamide-Cataract and Red Cell Binding 1961
• Acetazolamide and Hydrocephalus
• Acetazolamide and amloride VI Jpet, 1971
• Bar Harbor Teratology, 1972
• Beth II
• Dinsmore and Amphibia
• Acetazolamide-Data, Curves and Tables farm colony 1958 and 1959
• Acetazolamide and pseudo-tumors

 Box 58

• Hall HCO₃-Method Endolymph
• Endolymph Squalus Calc. Graphs 1974
• Endolymph and Meniers

 Box 59

• Mt. Sinai Work, 1979-1982
• Uppsala, 1977
• Correspondence etc.  1947-1953
• Correspondence 1951-1952
• Correspondence-Personal and FLA, 1955
• Letters from Friends and Family while Attending: Ophthamology Congress-Brussels (Sept. 1958)
• European Trip-Jan 1972
• European Trip-Jan 1973

 Box 60

• Merck, Data, Corr. 1985-1986
• 651461 Benzothiopheves, Merck
• Merck Corres. And Misc, 1980-1990
• Merck Correspondence, 1987-1990
• Merck Correspondence, 1992-1995

 Box 61

• A Misc, 1961-1975
• A 1978-1985
• Addink, A 1974
• Alcon 1980
• Allergan 1987-1990
• B Misc 1962-1979
• B 1967-1998
• Baker, Stephen 1991-1997
• Barany, Arnst, 1957-1990
• Bar-Ilah, A. 1988-1998
• Bentley, Peter. 1981-88
• Becker, Bernard, 1957-1992
• Botre, Claudio and Francesco, 1988-1998
• Berger (Personal Material) and Papers, 1960-1970
• Berger, Frank, 1972-95
• Boylan Obit-1992
• Bradbury, Michael, 1980-81
• Burgen, A. 1963-1991
• Burnett, Charles, 1967
• Butler, James N. 1984-86

 Box 62

• C-Cl 1982-1995
• Cm-Cz, 1981-1996
• Cade, Robert-Poems, 1997
• Case, Maynard, 1979-1998
• Clark, Dennis Cor. 1981
• C Mise
• Clark, Dennis, 1982
• Clark, Dennis, 1983
• Clark, Dennis, 1984
• Clark, Dennis Corr.  1985
• Clark, Dennis-1986-1987
• Chiov, George 1981-1995
• Cluff, Leighton 1965-1995
• Coe, Frederick 1990-1993
• D 1985-1998
• D Misc. 

Box 63

• Davson, Hugh 1957-1997
• Davson Symposium 1989
• Deal, Will 1981-1988
• Dodgson, Susanna 1978-1995
• College of Medicine-Dean Correspondence
• Dragstedt, Carl Poems
• Edelhauser, Henry F. 1969-1998
• Edsall, John T. 1961-1982
• English, Jackson P. 1957-1991
• F Misc. 1956-1967
• E Misc 1971-1998
• F-Fl 1983-1996
• Fm-Fz 1978-1999
• Famous, Maher 1991-1998
• Giles, F. Filley 1973-1989
• Fishman, Alfred P. 1962-1984

 Box 64

• Forster, Robert E. 1962-1998
• Fregly, Melvin 1996
• Freund, Gerhard (VA Hospital) 1970-1997
• Friedland, Beth 1974-1996
• G Misc. 1956-1979
• G-Gl 1980-1998
• Gm-Gz 1979-1997
• Giebisch, Gerhard 1972-1989
• Godman, David R. 1988-1994
• Goldstein, Avram 1981-1993
• Goldstein, Leon 1965-1995
• GAP 1996

Box 65

• Gyory, AZ 1971H Misc 1956-1979
• H-Hl 1980-1999
• Hm-Hz 1980-1998
• Harrell, G. T. 1955
• Harrell, G.T 1955-1998
• Henry, Raymond 1980-1997
• Higginbotham, Eve 1988-1989
• Hogben, A. 1964-66
• Holbrook, Karen A.  1994-1997
• Hoskins, Beth 1972-1982
• I Misc. 1982-1999
• Istin, M. 1971
• Ito, Susumu 1979-1983
• J Misc. 1980-1999

 Box 66

• Jankowska, Lidia 1981-1987
• K Misc. 1957-1981
• K-Kj 1981-1994
• Kl-Kz 1980-1997
• Correspondence, Alan Katritzky 1982-1987
• Kaufman, Herbert 1966-1985
• Khalifah, Raja
• King Patricia
• King, Rodney 1971-1992
• Kinng, Rolf 1988-1989
• Klein, Donald F., MD

Box 67

• Krupin, Theodore
• Correspondence “L” 1958-1987
• Correspondence “L” 1987-1990
• Lacy, Eric R.
• Langford, Herbert C.
• Langham, Maurice 1956-1959
• Lasagna, Louis, M.D.
• Laties, A 1989-1990
• Liljas, Anders
• Dr. Sven Lindskog
• Lippincott, Lincoln
• Lockhart, Madelyn

Box 68

• M-N-O Misc. 1964-1971
• Dr. Gerhard Malnic
• Maumenee, Edward (Dr.)
• Misc. Correspondence Mc
• Misc. Correspondence M-Ml
• Mittag, Thomas W.
• Merz, Dr. Kenneth, Jr.
• Modell, Jerome H.
• Misc. Correspondence N
• Nechay, B.

Box 69

• Neims, Allen H.
• Dr. Ernst A Noltmann
• Notelovitz, Morris, M.D.
• Misc. Correspondence O
• Walt Oppelt Memorial Scholarship
• Oppelt, W. Walter
• Oppelt, W. Walter
• Ophthalmology
• P-Q-R 1962-1977
• Correspondence P-Pl

Box 70

• Correspondence Pm-Pz
• Page, Dr. Irvine H.
• Palmer, Roger E.
• Pathology Review 1954-55
• Correspondence-Donald Price 1983-1995
• “R” Correspondence
• Richard Randall
• Floyd Rector Correspondence 1960-1986
• Reynolds, Dr. Richard
• Richardson-Merrell Correspondence 1967
• Richardson-Merrell 1969-1971
• Richardson-Merrell, 1972
• S 1966-1976

Box 71

• Correspondence S-Sh 1965-1999
• Correspondence Sl-So
• Correspondence Sp-Sz
• Correspondence Gautam Sanyal
• Schmidt-Nielson, Knut 1958-1978
• Correspondence George J. Schwartz
• Schwartz, William 1956-1978
• Schwartz Bioresearch 1956-1970
• Correspondence Marvin Sears
• Irving Segal

Box 72

• Correspondence John W. Severingham
• Sewing, K, 977
• Correspondence Stefan Silbernagl
• Correspondence David Silverman
• Correspondence William Sly
• Spicer
• Sprague, James 1962-63
• Correspondence Claudiu Supuran
• Dean Suter 1964-1967
• Swenson, Erik 1977
• T 1962-1979

Box 73

• Correspondence T. 1979-1996
• Correspondence Erik Swenson
• Correspondence Paul Talalay
• Correspondence Richard Tashian
• Brian Taschner
• Edward Taylor
• Correspondence U
• U and V Misc 1966-1979
• Correspondence Carl Ullrich
• Correspondence Borje Uvnas
• Correspondence V
• Correspondence Betty P. Vogh

Box 74

• W-X-Y-Z 1956-1979
• Correspondence W-Wh Misc
• Correspondence Wl-Wz Misc.
• Correspondence William Waddell
• Way, E. Leong 1995-1996′
• Corresp I.M. Weiner
• Correspondence Gerhard Werner

Box 75

• Correspondence Arnold Welch
• Correspondence re Dr. James G. Wilson, Children’s Hosp. And Wilson eulogy
• Wistrand, P. 1964-1965
• Correspondence Per Wistrand
• Correspondence X,Y.Z
• Correspondence Thom J. Zimmerman

Box 76

• National Board of Medical Examiners 1960-1969
• National Board 1976-1984
• Hopkins Alumni Educators
• AMSP 1970’s-1999 (Association for Medical School Pharm.)